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KMID : 0384320070280090705
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Korean Journal of Family Medicine
2007 Volume.28 No. 9 p.705 ~ p.711
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Association of Testosterone with Mebabolic Syndrome in Men Aged over 40 Years
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Kim Il-Bum
Huh Bong-Ryul
Kim Ji-Yeon
Son Jung-Sik
Oh Seung-Won
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Abstract
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Background: Recently, in our ageing society, the change in dietary pattern and increase in obesity have caused the metabolic syndrome to increase in Korea. Because of the association of the risk of cardiovascular diseases, the metabolic syndrome must be prevented and well managed. We examined the association between the metabolic syndrome and the serum testosterone and DHEA-S concentration.
Methods: The subject of this study included 231 men aged more than 40 years old who visited the health promotion center of a university hospital from March 2004 to March 2006. We excluded the subjects who were currently on medications except for antihypertensive and hypoglycemic agents. We defined the metabolic syndrome according to the ATP III with Asia-Pacific waist circumference. To examine the association between the metabolic syndrome and the serum testosterone concentration, we used the method of multiple logistic regression analysis.
Results: The prevalence of the metabolic syndrome in our subjects was 32.9%. Decreased serum testosterone concentration was significantly associated with large waist circumference and high fasting blood sugar. Men with testosterone values in the upper tertile had a significantly lower risk of metabolic syndrome (OR=0.34, P=0.018).
Conclusion: After statistical adjustment for age, smoking, income, exercise, alcohol intake, and body mass index, the serum testosterone concentration was negatively associated with the metabolic syndrome. (J Korean Acad Fam Med 2007;28:705-711)
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KEYWORD
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metabolic syndrome, testosterone, androgen
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